Thornybush Game Reserve, is a private game reserve, near Hoedspruit, in the Limpopo province of South Africa. It borders the Kapama Game Reserve and is located close to the Timbavati Game Reserve and the Kruger Park. The Reserve's surface area is approximately 11.000 Ha of mainly open savannah.
Thornybush Game Reserve features 147 mammals including the "Big Five" (see: Big Five game), 114 reptiles, 507 birds, 49 fish, 34 amphibians and 336 trees species.
As with many private reserves in South Africa, Thornybush is managed as an eco-tourism destination, thus the Reserve is funded by means of a number of up-market private commercial game lodges located within the Reserve.